Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus
Identifieur interne : 001622 ( Main/Exploration ); précédent : 001621; suivant : 001623Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus
Auteurs : Andong Wu [République populaire de Chine] ; Yi Wang [République populaire de Chine] ; Cong Zeng [République populaire de Chine] ; Xingyu Huang [République populaire de Chine] ; Shan Xu [République populaire de Chine] ; Ceyang Su [République populaire de Chine] ; Min Wang [République populaire de Chine] ; Yu Chen [République populaire de Chine] ; Deyin Guo [République populaire de Chine]Source :
- Virus Research [ 0168-1702 ] ; 2015.
Descripteurs français
- KwdFr :
- Alignement de séquences, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Cysteine endopeptidases (), Cysteine endopeptidases (génétique), Cysteine endopeptidases (métabolisme), Humains, Infections à coronavirus (virologie), Maturation post-traductionnelle des protéines, Modèles moléculaires, Peptides (génétique), Peptides (métabolisme), Phylogénie, Spécificité du substrat, Séquence d'acides aminés.
- MESH :
- enzymologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Cysteine endopeptidases, Peptides.
- métabolisme : Cysteine endopeptidases, Peptides.
- virologie : Infections à coronavirus.
- Alignement de séquences, Coronavirus du syndrome respiratoire du Moyen-Orient, Cysteine endopeptidases, Humains, Maturation post-traductionnelle des protéines, Modèles moléculaires, Phylogénie, Spécificité du substrat, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Coronavirus Infections (virology), Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (genetics), Cysteine Endopeptidases (metabolism), Humans, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (enzymology), Middle East Respiratory Syndrome Coronavirus (genetics), Models, Molecular, Peptides (genetics), Peptides (metabolism), Phylogeny, Protein Processing, Post-Translational, Sequence Alignment, Substrate Specificity.
- MESH :
- chemical , chemistry : Cysteine Endopeptidases.
- chemical , genetics : Cysteine Endopeptidases, Peptides.
- chemical , metabolism : Cysteine Endopeptidases, Peptides.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- classification : Middle East Respiratory Syndrome Coronavirus.
- enzymology : Middle East Respiratory Syndrome Coronavirus.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Amino Acid Sequence, Humans, Models, Molecular, Phylogeny, Protein Processing, Post-Translational, Sequence Alignment, Substrate Specificity.
Abstract
A prediction method of coronaviral 3CLpro cleavage sites was proposed to balance the accuracy and false positives. Three of the nine putative non-canonical cleavage sites were verified, which are located upstream to nsp4. All 11 canonical cleavage sites of MERS-CoV 3CLpro were confirmed and the Michaelis constants were calculated.
Url:
DOI: 10.1016/j.virusres.2015.05.018
PubMed: 26036787
PubMed Central: 7114542
Affiliations:
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Le document en format XML
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Medical Sciences, Wuhan University, Wuhan, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Basic Medical Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Coronavirus Infections (virology)</term><term>Cysteine Endopeptidases (chemistry)</term><term>Cysteine Endopeptidases (genetics)</term><term>Cysteine Endopeptidases (metabolism)</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term><term>Middle East Respiratory Syndrome Coronavirus (classification)</term><term>Middle East Respiratory Syndrome Coronavirus (enzymology)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Models, Molecular</term><term>Peptides (genetics)</term><term>Peptides (metabolism)</term><term>Phylogeny</term><term>Protein Processing, Post-Translational</term><term>Sequence Alignment</term><term>Substrate Specificity</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Cysteine endopeptidases ()</term><term>Cysteine endopeptidases (génétique)</term><term>Cysteine endopeptidases (métabolisme)</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Maturation post-traductionnelle des protéines</term><term>Modèles moléculaires</term><term>Peptides (génétique)</term><term>Peptides (métabolisme)</term><term>Phylogénie</term><term>Spécificité du substrat</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cysteine Endopeptidases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cysteine Endopeptidases</term><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Endopeptidases</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Cysteine endopeptidases</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cysteine endopeptidases</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Humans</term><term>Models, Molecular</term><term>Phylogeny</term><term>Protein Processing, Post-Translational</term><term>Sequence Alignment</term><term>Substrate Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Cysteine endopeptidases</term><term>Humains</term><term>Maturation post-traductionnelle des protéines</term><term>Modèles moléculaires</term><term>Phylogénie</term><term>Spécificité du substrat</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">A prediction method of coronaviral 3CLpro cleavage sites was proposed to balance the accuracy and false positives.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Three of the nine putative non-canonical cleavage sites were verified, which are located upstream to nsp4.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">All 11 canonical cleavage sites of MERS-CoV 3CLpro were confirmed and the Michaelis constants were calculated.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. 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Enjuanes</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement><orgName><li>Université de Wuhan</li></orgName></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Wu, Andong" sort="Wu, Andong" uniqKey="Wu A" first="Andong" last="Wu">Andong Wu</name></region><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><name sortKey="Guo, Deyin" sort="Guo, Deyin" uniqKey="Guo D" first="Deyin" last="Guo">Deyin Guo</name><name sortKey="Guo, Deyin" sort="Guo, Deyin" uniqKey="Guo D" first="Deyin" last="Guo">Deyin Guo</name><name sortKey="Huang, Xingyu" sort="Huang, Xingyu" uniqKey="Huang X" first="Xingyu" last="Huang">Xingyu Huang</name><name sortKey="Su, Ceyang" sort="Su, Ceyang" uniqKey="Su C" first="Ceyang" last="Su">Ceyang Su</name><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name><name sortKey="Xu, Shan" sort="Xu, Shan" uniqKey="Xu S" first="Shan" last="Xu">Shan Xu</name><name sortKey="Zeng, Cong" sort="Zeng, Cong" uniqKey="Zeng C" first="Cong" last="Zeng">Cong Zeng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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